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Table 2 Brca1 deficiency promotes mammary tumor initiation

From: Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

Genotype

p18 -/- -Donor A

p18 -/- ;Brca1 MGKO - Donor A

Number of tumor cell transplanted a

1x107/mouse

1x106/mouse

Experiment number

1

2

1

Tumor incidence b (7 weeks)

0/6

3/6 (50%) c

4/4 (100%)

Genotype

p18 -/- -Donor B

p16 -/- ;Brca1 MGKO - Donor A

Number of tumor cell transplanted a

3x106/mouse

1x106/mouse

Experiment number

1

2

1

Tumor incidence (6 weeks)

0/6

1/4 (25%) c

4/4 (100%)

  1. aUnsorted primary tumor cells were used
  2. bTumors generated larger than 12mm3 in size were counted
  3. cTumor cells were transplanted into MFPs of NSG mice with E2 supplement. A statistical significance from E2-treated and non-E2 treated groups combining both p18-/--Donor A and -B transplants by two tailed Fisher Exact test
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Breast Cancer Research

ISSN: 1465-542X

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