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Table 1 Deletion of Brca1 in p18 and p16 null epithelia induces estrogen receptor (ER)-negative mammary tumors

From: Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

Genotypea

Mammary tumor number

ERα + tumor number

% ERα + cells/tumor

Ck5/Ck14+ tumor number

% Ck5/Ck14+ cells/tumor

Wild-type

0/9

    

p18 −/−

7/15 (47%)

5/7 (71%)

2% - 50%

2/7 (29%)

2%, 5%

Brca1 MGKO b

1/13 (8%)

0/1

 

1/1(100%)c

20%

p18 −/− ;Brca1 MGKO

11/15 (73%)

2/11 (18%)d

2%, 5%

10/11 (82%)d

2–80%

p16 −/−

0/20

    

p16 −/− ;Brca1 MGKO

6/10 (60%)

0/6e

 

6/6(100%)e

2%-80%

  1. aAll mice were in the Balb/c-B6 mixed background and were at the age of 12–26 months
  2. bBrca1MGKO, Brca1f/f;MMTV-Cre or Brca1f/−;MMTV-Cre
  3. cA mouse with tumor harboring p53 mutation was 24 months of age
  4. dSignificance for p18−/−;Brca1MGKO and p18−/− tumors analyzed by the two-tailed Fisher’s exact test
  5. eSignificance for p16−/−;Brca1MGKO and p18−/− tumors analyzed by the two-tailed Fisher’s exact test
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Breast Cancer Research

ISSN: 1465-542X

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