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Table 3 CpG sites associated with serum 25(OH)D levels in subcohort (q < 0.10)

From: Vitamin D, DNA methylation, and breast cancer

CpG site

Location (Chr:position)

Location type

Gene

Effect estimatea (95% CI)

p value

q value

cg24350360

1:225997662b

TSS200

EPHX1

−0.04 (−0.06 to −0.03)

3.4 × 10−8

0.01

cg06177555

16:29678624

3′ UTR

SPN

−0.02 (−0.03 to −0.01)

9.8 × 10−8

0.02

cg13243168

17:61915833

Body

SMARCD2

−0.02 (−0.03 to −0.01)

2.9 × 10−7

0.04

cg23761815

10:73083123

Body

SLC29A3

−0.02 (−0.03 to −0.01)

5.1 × 10−7

0.05

cg10401362

7:157185402

Body

DNAJB6

−0.02 (−0.03 to −0.01)

1.0 × 10−6

0.09

  1. CI confidence interval, TSS200 within 200 basepairs upstream of the transcription start site, UTR untranslated region
  2. aEstimated change in methylation (logit(β)) per 10 ng/mL change in serum 25-hydroxyvitamin D (25(OH)D)
  3. bIntraclass correlation coefficient < 0.5