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Fig. 7 | Breast Cancer Research

Fig. 7

From: OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung

Fig. 7

Model of oncostatin M (OSM)-mediated metastasis. OSM is produced in an autocrine fashion by tumor cells (a), as well as by tumor-associated macrophages and neutrophils (b), for paracrine signaling. OSM promotes preintravasation effects, such as tumor cell detachment and migration, that can drive tumor cell intravasation into the circulation to develop circulating tumor cells and eventually metastasis. c When tumor cells are injected directly into the circulatory system, they bypass the multistep preintravasation aspects of metastases, and our data suggest that OSM has little effect on their extravasation and colonization at a secondary site

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