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Fig. 1 | Breast Cancer Research

Fig. 1

From: Murine breast cancer feed arteries are thin-walled with reduced α1A-adrenoceptor expression and attenuated sympathetic vasocontraction

Fig. 1

Vasocontraction of breast cancer feed arteries is attenuated compared to matched control arteries. Concentration-dependent contractions in response to norepinephrine (a) (n = 32), U46619 (b) (n = 12), endothelin-1 (c) (n = 19), and elevated extracellular K+ ([K+]o) (d) (n = 16) at pHo 7.4. Experiments with elevated [K+]o were performed in the presence of 1 μmol/L phentolamine in order to avoid the effects of norepinephrine released from sympathetic nerve endings in response to depolarization. Data were fitted to sigmoidal functions using least-squares regression analyses and curves compared by extra-sum-of-squares F tests. ***P < 0.001 vs. control

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