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Fig. 2 | Breast Cancer Research

Fig. 2

From: Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study

Fig. 2

a Hierarchical clustering analysis of all differentially expressed proteins (DEPs) (812 proteins at p ≤ 0.05 with ≥ 2 unique peptides). b Insulin signalling pathway significantly over-represented in DEPs between good and poor outcome groups (Fisher exact p = 0.015) using KEGG Pathway analysis with DAVID. Tabulation of gene names of the observed differentially expressed proteins constituent to the pathway presented. c MetaCore showed that glycolysis/gluconeogenesis was a significantly enriched process in the DEPs between good and poor outcome groups (FDR corrected p = 0.011). d Network analysis of differentially expressed proteins using Ingenuity Pathway Analysis showed participation of resistin in the small molecule biochemistry network (score = 23; focus molecules = 20)

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Breast Cancer Research

ISSN: 1465-542X

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