Fig. 5

Mammary tumor formation in p53^–/– mice. a Overall survival of BCCIP-CON and BCCIP-CKD mice with concurrent homozygous and hemizygous p53 deletions. b Mammary tumor-free survival of BCCIP-CON and BCCIP-CKD mice with concurrent homozygous and hemizygous p53 deletions. c HE stains of formalin-fixed paraffin-embedded sections from mammary tumors on BCCIP-CKD;p53^–/– females. Right panel shows a higher magnification from the highlighted area to show squamous cells within the tumors (yellow arrows). d IHC of breast cancer derived from BCCIP-CKD and p53^–/– mice. Right panel shows a higher magnification of clusters of BCCIP positive cells (black arrows) within the mostly BCCIP negative tissue in the tumor specimens. CKD FVB:LoxPshBCCIP ^+/− ;K14-Cre ^+/−, CON FVB:LoxPshBCCIP ^+/− ;K14-Cre ^−/−