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Table 3 Protein targets significantly associated with recurrence-free survival (RFS)

From: Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors

Target

HR

95% CI

P value

FDR

Affiliation

SHMT2

1.88

1.50–2.36

<0.001

<0.001

Serine metabolism

ASCT2

1.83

1.45–2.31

<0.001

<0.001

Glutamine metabolism

GAPDH

1.52

1.19–1.94

<0.001

0.009

Glucose metabolism

FH

1.65

1.20–2.27

0.002

0.019

TCA cycle

CAD

2.07

1.29–3.33

0.003

0.019

Pyrimidine metabolism

PKM2

1.46

1.13–1.88

0.003

0.02

Glucose metabolism

  1. RFS events = 109
  2. HR hazard ratio, FDR false-discovery rate, CI confidence interval, SHMT2 serine hydroxymethyltransferase 2, ASCT2 ASC amino-acid transporter 2, GAPDH glyceraldehyde-3-phosphate dehydrogenase, TCA tricarboxylic acid, FH fumarate hydratase, CAD carbamoyl-phosphate synthetase 2, PKM2 pyruvate kinase 2
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Breast Cancer Research

ISSN: 1465-542X

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