White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

Sturgeon, Susan R.; Pilsner, J. Richard; Arcaro, Kathleen F.; Ikuma, Kaoru; Wu, Haotian; Kim, Soon-Mi; Chopra-Tandon, Nayha; Karpf, Adam R.; Ziegler, Regina G.; Schairer, Catherine; Balasubramanian, Raji; Reckhow, David A.

doi:10.1186/s13058-017-0886-6

Table 1 Associations between demographic and lifestyle characteristics and risk of breast cancer, adjusted for age and time of entry into the cohort

From: White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

	Controls	%	Cases	%	Odds Ratio, 95% CI
Age (years)
<59	150	35.8	151	35.3	1.0 (referent)
60–64	140	33.4	141	32.9	1.00	0.72	1.39
65–69	93	22.2	102	23.8	1.09	0.76	1.56
> =70	36	8.6	34	7.9	0.94	0.56	1.58
Time of entry
> =October 10, 1997	168	40.1	174	40.7	1.0 (referent)
< =September 30, 1997	251	59.9	254	59.4	1.02	0.78	1.35
Race
White, non-Hispanic	380	90.7	395	92.3	1.0 (referent)
Other	39	9.3	33	7.7	0.81	0.50	1.32
Body mass index (kg/m²)
Underweight-normal (15–24.99)	175	41.9	176	41.2	1.0 (referent)
Overweight (25.0–29.99)	141	33.7	152	35.6	1.07	0.79	1.46
Obese (> = 30)	102	24.4	99	23.2	0.96	0.68	1.36
Age at menarche (years)
<12	70	16.8	88	20.6	1.0 (referent)
12–13	238	56.9	219	51.2	0.73	0.51	1.05
> =14	110	26.3	121	28.3	0.87	0.58	1.31
Number of live births
None	31	7.4	48	11.2	1.0 (referent)
1–2 births	123	29.4	147	34.4	0.77	0.46	1.29
3+ births	265	63.3	233	54.4	0.57	0.35	0.92
Age at first birth (years)
<20	72	17.2	55	12.9	1.0 (referent)
20–24	209	49.9	181	42.5	1.14	0.76	1.70
25–29	80	19.1	108	25.4	1.77	1.12	2.79
> =30	27	6.4	34	8.0	1.66	0.89	3.07
Nulliparous	31	7.4	48	11.3	2.03	1.14	3.59
Type of menopause
Natural	253	60.4	283	66.1	1.0 (referent)
Bilateral oophorectomy	49	11.7	29	6.8	0.52	0.31	0.85
Other	117	27.9	116	27.1	0.88	0.65	1.20
Age at natural menopause (years)
<50	91	36.0	95	33.7	1.0 (referent)
50–54	122	48.2	141	50.0	1.15	0.79	1.69
55+	40	15.8	46	16.3	1.15	0.69	1.93
History of benign breast disease
No	285	69.9	261	61.9	1.0 (referent)
Yes	123	30.2	161	38.2	1.43	1.07	1.91
Smoking status
Never	257	61.3	229	53.5	1.0 (referent)
Former	135	32.2	163	38.1	1.36	1.02	1.82
Current	27	6.4	36	8.4	1.51	0.89	2.56
Recent alcohol intake
No	112	29.2	99	24.9	1.0 (referent)
Yes	272	70.8	298	75.1	1.25	0.91	1.72
Family history of breast cancer
No	353	85.9	340	81.0	1.0 (referent)
Yes	58	14.1	80	19.1	1.43	0.99	2.07
Hormone user
Never	111	26.7	102	23.9	1.0 (referent)
Former	70	16.8	55	12.9	0.86	0.55	1.34
Current	235	56.5	269	63.2	1.26	0.91	1.75

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ISSN: 1465-542X

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