Fig. 4

BV module for metasynchronous metastatic spread. a Discovery of the BV module. BV module scores, shown as density plots for each metastatic group in the estrogen-receptor-positive case-control paired breast cancer cases from the discovery set (GWDb) together with the corresponding receiver operating characteristic curve for the bone and visceral group. b Estimated BV expression score based on NanoString nCounter quantification compared with those obtained from the WG-DASL platform. c Correlation plot displaying the BV gene set in primary tumours and their matched lymph node metastases. Points are colour-coded according to metastatic group. d BV module scores in lymph node metastases of the GSE46141 data, displayed according to their reported patterns of first metastatic spread