Fig. 5

Effects of selinexor on tumor growth in combination with standard chemotherapy. Mice bearing three different triple-negative breast cancer patient-derived xenografts were treated with vehicle, selinexor 12.5 mg/kg twice a week for BCX 10 and once weekly for BCX 6 and BCX 11, paclitaxel 10 mg/kg weekly, eribulin 1 mg/kg, carboplatin 75 mg/kg weekly, and combinations of selinexor with each chemotherapy agent. a Values are presented as mean ± SEM. The tumor volumes at the conclusion of the experiment were compared with vehicle, and the data were analyzed by two-way analysis of variance to determine statistical significance. b Tumor growth inhibition (T/C) ratios were calculated using the formula: [(Median tumor volume of treated group)/(Median tumor volume of control group)] × 100. Activity was defined as a T/C % ratio <40%