Fig. 5
AKT1low quiescent cancer cells (QCCs) in primary tumors from patients with triple negative breast cancer persist after multi-agent, multi-cycle neoadjuvant chemotherapy (NACT). a QCC percentage appeared to increase in primary breast tumor tissue after NACT (p = 0.017) Paired samples are shown by dotted lines. b QCC cluster index is preserved in primary breast tumor tissue after NACT (p = 0.056). c Graphical summary of a and b showing that QCC percentage and clustering persist in post-treatment primary breast tumors after treatment with anthracycline, taxane, platinum-based chemotherapy, and mTOR inhibitors and VEGF inhibitors (red dots, QCCs; blue dots, non-QCCs)