miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer

Table 2 Univariate and multivariate analyses of prognostic factors for overall survival, disease-free survival, distant metastasis-free survival, and locoregional recurrence-free survival

Variables	OS				DFS				DMFS				LRRFS
	Univariate	Multivariate			Univariate	Multivariate			Univariate	Multivariate			Univariate	Multivariate
	P value	HR	95% CI	P value	P value	HR	95% CI	P value	P value	HR	95% CI	P value	P value	HR	95% CI	P value
Age (years)	0.478				0.384				0.220				0.245
Menopause	0.594				0.910				0.852				0.994
T	<0.001	1.2	0.9–1.5	0.069	<0.001	1.2		0.041	<0.001	1.2	0.9–1.5	0.095	<0.001	1.3	0.9–1.7	0.053
N	<0.001	1.3	1.0–1.6	0.034	<0.001	1.4		0.007	<0.001	1.3	1.1–1.7	0.012	<0.001	1.3	0.9–1.8	0.083
TNM stage	<0.001	1.8	1.1–2.9	0.016	<0.001	1.6		0.021	<0.001	1.9	1.2–2.9	0.007	<0.001	1.4	0.8–2.5	0.247
Surgery	0.774				0.985				0.784				0.610
Chemotherapy	0.167				0.180				0.192				0.057
Grade	0.016	1.4	1.1–1.8	0.004	0.003	1.4		0.001	0.002	1.5	1.2–1.9	<0.001	0.254
Ki-67	0.391				0.499				0.523				0.401
LVI	<0.001	2.0	1.4–2.9	<0.001	<0.001	1.4		0.047	<0.001	1.6	1.1–2.3	0.008	0.045	0.9	0.6–1.7	0.971
miR-629-3p	<0.001	1.3	0.9–1.8	0.089	0.002	1.1		0.558	<0.001	1.2	0.9–1.7	0.191	0.116

Abbreviations: DFS Disease-free survival, DMFS Distant metastasis-free survival, LRRFS Locoregional recurrence-free survival, LVI Lymphovascular invasion

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