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Table 4 The associations of weight and height with pubertal outcomes, by breast cancer family history (BCFH)

From: Pubertal development in girls by breast cancer family history: the LEGACY girls cohort

 

Odds ratio (95% confidence interval)

Overall

BCFH+ girls

BCFH– girls

Breast Tanner stage T2 + a

 n

786

383

403

 Model 1c

 Weight (per 1 kg)

1.09 (1.05–1.12)

1.06 (1.03–1.10)

1.14 (1.04–1.24)

 Height (per 1 cm)

1.03 (0.99–1.07)

1.03 (0.99–1.08)

1.01 (0.94–1.09)

 Race/ethnicity

  Non-Hispanic white

1.00 (reference)

1.00 (reference)

1.00 (reference)

  Asian

0.55 (0.22–1.41)

0.66 (0.18–2.37)

0.55 (0.16–1.86)

  Black

3.88 (1.74–8.65)

5.04 (1.21–20.94)

3.80 (1.43–10.11)

  Hispanic

1.18 (0.65–2.13)

1.34 (0.58–3.14)

0.91 (0.37–2.25)

  Mixed race/ethnicity

2.54 (0.75–8.54)

7.61 (0.11–533.98)

1.81 (0.56–5.78)

 Model 2d

 Overweight (≥85th percentile)

4.65 (2.58–8.38)

3.32 (1.43–7.69)

6.72 (2.70–16.74)

Pubic hair Tanner stage T2 + a

 n

819

403

416

 Model 1c

 Weight (per 1 kg)

1.02 (0.99–1.05)

1.02 (0.98–1.06)

1.02 (0.98–1.06)

 Height (per 1 cm)

1.06 (1.03–1.10)

1.05 (1.00–1.11)

1.07 (1.02–1.12)

 Race/ethnicity

   Non-Hispanic white

1.00 (reference)

1.00 (reference)

1.00 (reference)

   Asian

0.44 (0.21–0.95)

0.39 (0.13–1.20)

0.46 (0.17–1.24)

   Black

5.27 (2.38–11.65)

9.58 (2.53–36.19)

3.88 (1.48–10.17)

   Hispanic

1.55 (0.85–2.84)

1.71 (0.65–4.47)

1.36 (0.60–3.11)

   Mixed race/ethnicity

1.46 (0.37–5.77)

2.45 (0.54–11.05)

1.09 (0.16–7.53)

 Model 2d

 Overweight (≥85th percentile)

1.24 (0.75–2.06)

1.26 (0.56–2.83)

1.40 (0.71–2.75)

Post-menarche statusb

 n

493

260

233

 Model 1c

 Weight (per 1 kg)

1.08 (1.04–1.12)

1.09 (1.03–1.16)

1.06 (1.00–1.12)

 Height (per 1 cm)

1.03 (0.99–1.08)

0.98 (0.93–1.05)

1.09 (1.03–1.16)

 Race/ethnicity

   Non-Hispanic white

1.00 (reference)

1.00 (reference)

1.00 (reference)

   Asian

1.06 (0.46–2.45)

0.52 (0.15–1.81)

1.60 (0.46–5.58)

   Black

1.69 (0.65–4.40)

1.37 (0.34–5.51)

2.07 (0.50–8.54)

   Hispanic

2.41 (1.15–5.04)

1.22 (0.49–3.09)

8.08 (2.24–29.19)

   Mixed race/ethnicity

2.21 (0.20–23.96)

0.29 (0.02–3.51)

5.28 (0.06–480.69)

 Model 2d

 Overweight (≥85th percentile)

4.19 (2.15–8.14)

4.75 (2.08–10.82)

3.73 (1.21–11.51)

  1. aExcludes girls aged ≥13 years (n = 135)
  2. bExcludes girls aged <10 years (n = 510)
  3. cModel includes weight, height, race/ethnicity, and is adjusted for age and study site. Non-Hispanic white is the referent race/ethnicity
  4. dModel includes overweight and is adjusted for height, race/ethnicity, age, and study site. Non-Hispanic white is the referent race/ethnicity
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Breast Cancer Research

ISSN: 1465-542X

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