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Fig. 1 | Breast Cancer Research

Fig. 1

From: Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer

Fig. 1

Relationship between biomarkers and pathologic complete response (pCR) by treatment group. CR concentration ratio, cyt cytoplasmic, EGF epidermal growth factor, EGFR epidermal growth factor receptor, IGF1R insulin-like growth factor 1 receptor, Mem membranous, Mut mutant, Nuc nuclear, PIK3CA gene encoding phosphoinositide 3-kinase catalytic subunit, PTEN phosphatase and tensin homolog, qRT-PCR quantitative reverse transcription polymerase chain reaction, sHER2 serum HER2 extracellular domain, TGF transforming growth factor, WT wild-type

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