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Fig. 6 | Breast Cancer Research

Fig. 6

From: Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

Fig. 6

Genetic instability in mammary gland tumor tissue of chronically insulin analogue-exposed mice. a The bar plot shows the average number of mutations per MG tumor for all chronic treatments; the dot plot indicates that there is no correlation between the number of mutations of a specific tumor and tumor latency time. b The same as in a, but here we focus on clinically relevant human tumor driver mutations. c Some specific tumor driver mutations are featured in these bar plots. The first bar plot represents the mutations that are enriched in the X10/IGF1 treatment groups; in the second bar plot, the mutations are highlighted that are under-represented in the vehicle treatment group. N shows the number of tumors in which this specific mutation was present

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