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Fig. 3 | Breast Cancer Research

Fig. 3

From: Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

Fig. 3

Tissue invasion and metastasis in mammary gland tumor tissue of chronically insulin analogue exposed mice. a Hierarchical clustering (Pearson correlation) of genes involved in epithelial to mesenchymal transition (EMT) or mesenchymal to epithelial transtition (MET) per MG tumor. The pie diagrams show the distribution of the different treatments in the three clusters. b The E-cadherin/HOECHST immunofluorescent hematoxylin and eosin (H&E) pathology slides of three example tumors showing epithelial or mesenchymal characteristics. c Bar graph of SVM simulation on the predicted migration potential per treatment of MG tumors of the chronically exposed mice (i) and human breast cancer cells (MCF7 IGF1R) exposed for 1 h to the indicated insulin analogue (ii). *P < 0.05. ns not significant

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