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Table 3 Uni- and multivariate analysis using metabolic PET parameters and clinicopathologic factors for EFS

From: 18FDG-PET/CT for predicting the outcome in ER+/HER2- breast cancer patients: comparison of clinicopathological parameters and PET image-derived indices including tumor texture analysis

Parameters

Univariate analysis

Multivariate analysis

P value

P value

Hazard ratio (95% CI)

Age

0.10

Not included

Histology

0.02

0.02

3.80 (1.22ā€“11.80)

Grade

0.60

Not included

PR expression

0.01

0.03

2.90 (1.12ā€“7.49)

Tumor classification

0.09

Not included

Lymph node classification

0.24

Not included

Stage

0.05a

Not included

SUVmax

<0.01

Not retained in the final model

SUVmean

0.01

Not retained in the final model

SUVpeak

<0.01

Not retained in the final model

MATV

<0.01

<0.01

1.01 (1.00ā€“1.02)b

TLG

<0.01

Not retained in the final model

Entropy

0.02

Not retained in the final model

Homogeneity

0.02

Not retained in the final model

  1. P value corresponds to Cox proportional hazard regression model. Hazard ratios were calculated with their 95% confidence interval (CI). Bold numerals correspond to statistically significant P values
  2. PET positron emission tomography, EFS event-free survival, PR progesterone receptor, SUV standardized uptake value, MATV metabolically active tumor volume, TLG total lesion glycolysis, H homogeneity, E entropy
  3. aNot significant after multiple testing correction
  4. bHR for MATV was calculated on a continuous variable (if MATV increase from 1Ā ml, the risk of relapse increase of 1%)