18FDG-PET/CT for predicting the outcome in ER+/HER2- breast cancer patients: comparison of clinicopathological parameters and PET image-derived indices including tumor texture analysis

Table 2 Relation between some clinical or tumor characteristics and tumor PET-derived image parameters in 143 patients with ER+/HER2- breast cancer

		Age				Tumor^a		Lymph nodes^a		Histology		Grade		PR expression
		≤40	>40	≤50	>50	T2	T3	N0	N+	IDC	ILC	1–2	3	Neg	Pos
No. patients		27	116	74	69	53	56	58	85	129	7	98	42	55	88
SUV_max	med	5.4	6.8	6.5	6.6	5.2	5.9	6.1	6.6	6.8	4.8	5.4	7.9	7.2	5.7
SUV_max	P	0.31		0.63		0.56		0.79		0.43		<0.01		0.06
SUV_mean	med	3.1	3.6	3.4	3.6	2.9	3.3	3.5	3.5	3.6	3.0	3.1	4.2	4.0	3.2
SUV_mean	P	0.36		0.67		0.59		0.77		0.31		<0.01		0.06
SUV_peak	med	4.3	5.3	5.1	5.1	4.1	4.9	4.9	5.1	5.2	4.4	4.4	6.4	5.7	4.5
SUV_peak	P	0.32		0.60		0.44		0.81		0.63		<0.01		0.05^b
MATV	med	10.1	11.2	11.0	9.6	6.7	10.8	9.2	11.3	10.1	32.5	10.9	10.4	13.9	9.1
MATV	P	0.33		0.86		<0.01		0.24		0.02^b		0.83		0.03^b
TLG	med	27.2	39.0	33.5	35.2	20.1	33.5	32.7	40.5	32.8	74.6	32.1	44.8	46.3	28.2
TLG	P	0.22		0.86		<0.01		0.41		0.16		0.05^b		0.01^b
H	med	0.12	0.12	0.12	0.12	0.11	0.12	0.12	0.12	0.12	0.14	0.12	0.12	0.13	0.12
H	P	0.81		0.87		0.02		0.10		0.09		0.73		0.12
E	med	3.5	3.8	3.7	3.6	3.2	3.7	3.5	3.8	3.6	4.8	3.7	3.7	4.0	3.5
E	P	0.18		0.97		<0.01		0.25		0.02^b		0.70		0.02^b

P value for comparison of median values with the Wilcoxon rank sum test. Bold numerals correspond to P values keeping statistically significant after multiple corrections from Benjamini-Hochberg
PET positron emission tomography, ER+/HER2- estrogen receptor-positive/human epidermal growth factor receptor 2-negative, PR progesterone receptor, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, SUV standardized uptake value, MATV metabolically active tumor volume, TLG total lesion glycolysis, H homogeneity, E entropy
^aClinical classification according to the seventh edition of the AJCC Cancer Staging Manual
^bNot significant after correction for multiple testing

ISSN: 1465-542X