|  |  | Partially adjusteda | Fully adjustedb | ||
---|---|---|---|---|---|---|
Patients (N) | Deaths (N) | HR (95Â % CI) | P value | HR (95Â % CI) | P value | |
All cancers | ||||||
 Low KI67 | 6093 | 1030 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 1995 | 371 | 2.32 (1.79–3.00) | 6.34 × 10−11 | 1.47 (1.13–1.92) | 0.004 |
T c |  |  | 0.89 (0.84–0.94) | 3.20 × 10−5 | 0.93 (0.87–0.98) | 0.010 |
ER-positive | ||||||
 Low KI67 | 4379 | 615 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 1141 | 166 | 2.47 (1.63–3.72) | 8.45 × 10−6 | 1.96 (1.31–2.93) | 0.001 |
T |  |  | 0.88 (0.81–0.96) | 0.003 | 0.89 (0.82–0.97) | 0.006 |
ER-negative | ||||||
 Low KI67 | 1271 | 320 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 778 | 188 | 1.38 (0.97–1.97) | 0.072 | 1.23 (0.86–1.77) | 0.248 |
T |  |  | 0.94 (0.86–1.02) | 0.155 | 0.94 (0.87–1.03) | 0.199 |
ER-positive/node-positive | ||||||
 Low KI67 | 1550 | 350 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 408 | 94 | 2.22 (1.31–3.77) | 0.003 | 1.74 (1.05–2.86) | 0.031 |
T |  |  | 0.91 (0.82–0.99) | 0.044 | 0.91 (0.82–1.01) | 0.075 |
ER-positive/node-negative | ||||||
 Low KI67 | 2399 | 205 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 561 | 55 | 3.17 (1.43–6.99) | 0.004 | 2.47 (1.16–5.27) | 0.019 |
T |  |  | 0.84 (0.71–0.98) | 0.034 | 0.86 (0.73–0.99) | 0.048 |
HRP/HER2– | ||||||
 Low KI67 | 3332 | 462 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 831 | 114 | 1.69 (1.26–2.27) | 2.42 × 10−4 | 1.49 (1.10–2.00) | 0.009 |
T |  |  | 0.94 (0.90–0.98) | 0.004 | 0.94 (0.90–0.98) | 0.004 |
HRP/HER2+ | ||||||
 Low KI67 | 421 | 82 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 157 | 36 | 1.96 (1.28–3.00) | 9.70 × 10−4 | 1.59 (1.03–2.45) | 0.035 |
T |  |  | 0.94 (0.90–0.98) | 0.004 | 0.94 (0.90–0.98) | 0.004 |
HRN/HER2– (triple-negative) | ||||||
 Low kI67 | 565 | 142 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 436 | 107 | 1.75 (1.06–2.90) | 0.028 | 1.70 (1.02–2.84) | 0.044 |
T |  |  | 0.86 (0.75–0.98) | 0.031 | 0.86 (0.75–0.99) | 0.031 |
HRN/HER2+ (HER2-enriched) | ||||||
 Low KI67 | 227 | 85 | 1.00 (referent) |  | 1.00 (referent) |  |
 High KI67 | 149 | 48 | 0.76 (0.37–1.55) | 0.450 | 0.75 (0.36–1.57) | 0.455 |
T |  |  | 1.08 (0.90–1.29) | 0.396 | 1.07 (0.90–1.29) | 0.435 |