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Table 1 Overview of studies that compared surgery with radiotherapy alone after neoadjuvant chemotherapy

From: Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials

Study

Study period

n

cCR

Locoregional treatment

5-year overall survival

5-year LRR

    

Surgery

RT alone

Surgery (%)

RT alone (%)

Surgery (%)

RT alone (%)

De Lena et al. [11]

1975–1980 prospective

132 T3b-4 N0-2

100 % RT group; 60 % surgery group

65

67

49.1a

51.7a

29.6

31.1

Perloff et al. [9]

1978–1983 prospective

87

18 %

43

44

63b

50b

19

27

Scholl et al. [8]

1986–1990

200

?

36 Mtx ± RT, 62 BCS + RT

102

–

–

24

 

Touboul et al. [6]

1982–1990 prospective

97

33

37 rD (>3 cm), Mtx; 27 rD (<3 cm), BCS

33

83.3

75.7

16 after BCS, 5.4 after Mtx

16

Ellis et al. [12]

1985–1994

185

39

120; 29 Mtx, 91 BCS

39

76

84

7

21

Mauriac et al. [7]

1985–1989

134 T2-3

 

89; 40 BCS = RT, 49 Mtx

44

–

–

22.5 BCS + RT, 22.4 after Mtx

34

Ring et al. [13]

1986–1999

453

136

67

69

74

76

10

21

Daveau et al. [10]

1985–1999

1477 T2-3

165

65

100

82

91

12

23

  1. aFour-year overall survival
  2. bOverall survival at 39 months
  3. BCS breast conserving surgery, cCR clinical complete remission, LRR locoregional recurrence, Mtx mastectomy, rD residual disease, RT radiotherapy