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Table 2 Clinico-pathological parameters of 201 human breast tumor specimens in relation to CREB3L1 gene methylation

From: Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

 

CREB3L1 methylationb

 

Numbera

Low

High

P valuec

Spearman r

Parameter:

Age at diagnosis

 <68 years

100

79

21

0.018

−0.166

 ≥68 years

101

89

12

  

Tumor type

 Infiltrating ductile

149

127

22

0.034

0.150

 Infiltrating colloid

21

21

0

  

 Infiltrating lobular

29

18

11

  

 Infiltrating papillary

1

1

0

  

 Infiltrating tubular

1

1

0

  

Tumor graded

 Grade 4

12

9

3

0.038

0.146

 Grade 5

50

48

2

  

 Grade 6

49

41

8

  

 Grade 7

23

18

5

  

 Grade 8

57

44

13

  

 Grade 9

10

8

2

  

Estrogen receptor

 Negative

14

11

3

0.017

−0.168

 Positive

187

157

30

  

Progesterone receptor

 Negative

54

42

12

0.042

−0.143

 Positive

147

126

21

  

Lymph node status

 Negative

65

52

13

0.532

−0.050

 Positive

93

77

16

  

 Unknown

43

39

4

  
  1. aOnly patients with primary breast cancer were included. bBased on DNA sequencing results with and without sodium bisulfite treatment. cSignificance of Spearman rank correlation. Significant p values are marked in boldface. dGraded according to the Nottingham derivation of the Scarff Bloom Richardson system