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Fig. 3 | Breast Cancer Research

Fig. 3

From: Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Fig. 3

High frequency of TICs in PDA and spindle tumors. a Schematic illustration of the experimental design used to analyze TIC frequency in the four major tumor types. b Tumor-initiating cell (TIC) frequency in the major tumor subtypes in WAP-Cre:Ptenfl/fl:p53R270H/wt mice, showing high frequency in PDA and spindle tumors. c Histology of secondary tumors showing a selection for spindle-like tumors. For PDAs - 5/16 secondary tumors remained PDAs, and the rest (11/16) became spindle. For AME tumors, 4/4 secondary were all spindle-like. All primary spindle tumors gave spindle secondary tumors. AME adenomyoepithelioma, PDA poorly differentiated adenocarcinoma

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Breast Cancer Research

ISSN: 1465-542X

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