Skip to main content
Fig. 2 | Breast Cancer Research

Fig. 2

From: Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Fig. 2

Analysis of mutant p53 accumulation in tumor cells. a-c p53 IHC of WAP-Cre:Ptenfl/fl:p53R270H/wt tumors showing lack of p53 accumulation, indicating the p53R270H allele was not activated in (a). Arrows and dashed outlines indicate a region with strong p53 accumulation; arrowheads and dotted outlines to regions with weak or no p53 accumulation (b). Note strong nuclear accumulation of mutant p53 in tumor cells (c). d Summary of mutant p53 accumulation in the major tumor types in WAP-Cre:Ptenfl/fl:p53R270H/wt mice: mixed, n = 9; squamous, n = 4; AME, n = 9; spindle, n = 12; PDA, n = 6. AME adenomyoepithelioma, IHC immmunohistochemistry, PDA poorly differentiated adenocarcinoma

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us