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Fig. 5 | Breast Cancer Research

Fig. 5

From: Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state

Fig. 5

Ectopic expression of human telomerase reverse transcriptase (hTERT) rescues chromosomal instability phenotype of breast primary epithelial cells (BPECs). a Growth kinetics of 04BPEC-hTERT and 05BPEC-hTERT. b mRNA levels of hTERT assessed by qRT-PCR in 12BPEC-hTERT versus finite (non-tranduced) BPECs. c Frequencies of chromosomes with telomere signal-free ends are dramatically reduced after transduction with hTERT (12BPEC at PD25 and 12BPEC-hTERT at PD21). d Reduced frequencies of structural chromosome rearrangements after transduction with hTERT (12BPEC at PD25 and 12BPEC-hTERT at PD21). e Frequencies of tetraploid nuclei are reduced after transduction with hTERT (12BPEC at PD25 and 12BPEC-hTERT at PD21)

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