Univariate analysis | Multivariate analysis | ||||||||
---|---|---|---|---|---|---|---|---|---|
Parameter | N | % pCR | OR | 95 % CI | P value | OR | 95 % CI | P value | |
Clinical T stage | cT1/cT2 | 106 | 17.9 | 1 | Reference | 1 | Reference | ||
cT3/T4 | 73 | 6.8 | 0.34 | 0.12–0.95 | 0.039 | 0.49 | 0.16–1.50 | 0.209 | |
Clinical N stage | cN0 | 84 | 21.4 | 1 | Reference | 1 | Reference | ||
cN+ | 95 | 6.3 | 0.25 | 0.09–0.66 | 0.005 | 0.19 | 0.06–0.58 | 0.003 | |
HR status | ER+ and/or PR+ | 151 | 8.6 | 1 | Reference | 1 | Reference | ||
Triple negative | 28 | 39.3 | 6.87 | 2.66–17.7 | 0.00007 | 9.35 | 3.09–28.3 | 0.00008 | |
Allocated treatment | TAC + ZA | 87 | 14.9 | 1 | Reference | 0.559 | |||
TAC only | 92 | 12.0 | 0.77 | 0.33–1.83 | |||||
Age | 0.96 | 0.89–1.09 | 0.186 | ||||||
BMI | 0.97 | 0.88–1.08 | 0.581 | ||||||
rs10735380 | AA | 97 | 13.4 | 1 | Reference | ||||
IGF1 | AG | 66 | 13.6 | 1.02 | 0.41–2.55 | 0.966 | |||
GG | 5 | 20.0 | 1.61 | 0.17–15.6 | 0.679 | ||||
rs1520220 | CC | 111 | 15.3 | 1 | Reference | ||||
IGF1 | CG | 45 | 13.3 | 0.85 | 0.31–2.32 | 0.752 | |||
GG | 11 | 0.0 | – | – | – | ||||
rs6220 | AA | 88 | 11.4 | 1 | Reference | ||||
IGF1 | AG | 56 | 16.1 | 1.49 | 0.57–3.94 | 0.418 | |||
GG | 17 | 17.6 | 1.67 | 0.41–6.48 | 0.475 | ||||
rs2270628 | CC | 101 | 11.9 | 1 | Reference | ||||
IGFBP3 | CT | 45 | 17.8 | 1.60 | 0.61–4.24 | 0.342 | |||
TT | 9 | 0.0 | – | – | – | ||||
rs2854746 | GG | 55 | 7.3 | 1 | Reference | 1 | Reference | ||
IGFBP3 | GC | 72 | 16.7 | 2.55 | 0.78–8.40 | 0.124 | 3.06 | 0.82–11.4 | 0.097 |
CC | 33 | 21.2 | 3.43 | 0.92–12.8 | 0.066 | 4.02 | 0.92–17.6 | 0.065 | |
GG | 55 | 7.3 | 1 | Reference | 1 | Reference | |||
GC/CC | 105 | 18.1 | 2.82 | 0.91–8.74 | 0.073 | 3.35 | 0.96–11.7 | 0.058 | |
rs4320932 | TT | 106 | 15.1 | 1 | Reference | ||||
IGF2 | TC | 57 | 12.3 | 0.79 | 0.30–2.04 | 0.623 | |||
CC | 8 | 12.5 | 0.80 | 0.09–6.98 | 0.843 | ||||
rs2016347 | GG | 45 | 4.4 | 1 | Reference | 1 | Reference | ||
IGF1R | GT | 94 | 17.0 | 4.41 | 0.97–20.1 | 0.055 | 5.58 | 1.08–28.7 | 0.040 |
TT | 32 | 15.6 | 3.98 | 0.72–22.0 | 0.113 | 6.67 | 1.03–43.1 | 0.046 | |
GG | 45 | 4.4 | 1 | Reference | 1 | Reference | |||
GT/TT | 126 | 16.7 | 4.30 | 1.00–19.1 | 0.056 | 5.82 | 1.17–29.1 | 0.032 |