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Fig. 4 | Breast Cancer Research

Fig. 4

From: The relationship between quantitative human epidermal growth factor receptor 2 gene expression by the 21-gene reverse transcriptase polymerase chain reaction assay and adjuvant trastuzumab benefit in Alliance N9831

Fig. 4

Hazard ratio for trastuzumab benefit as a continuous function of HER2 expression by RT-PCR. Estimate and 95 % confidence limits obtained from a Cox PH model for DRFI with a main effect for treatment arm (C versus A), a natural cubic spline for the main effect of HER2 by RT-PCR, a natural cubic spline for the interaction of HER2 by RT-PCR with treatment arm, and three indicator variables to adjust for nodal status (0, 1–3, 4–9 and 10+ positive nodes). Solid line = estimate of hazard ratio; dashed lines = lower and upper 95 % confidence limits. DRFI distant recurrence-free interval, HER2 human epidermal growth factor receptor 2, RT-PCR reverse transcriptase polymerase chain reaction

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