Fig. 5

Correlation between miRNA expression and histone methylation patterns. The histone marks H3K4me3 and H3K27me3 correlate with miRNA expression. Results are shown for the top 200 (scatter plot) or 140 (heatmap) differentially expressed miRNAs between the luminal progenitor (LP) and MaSC/basal (MS) subsets and for the top 200 (scatter plot) or 140 (heatmap) differentially expressed (DE) miRNAs between the mature luminal (ML) and LP subsets. a Scatter plots show that expression changes between the MS and LP subsets are directly correlated with differential H3K4me3 marking (top panel, P = 0.017) and inversely correlated with H3K27me3 marking (bottom panel, P = 9.6 × 10^-5). b Scatter plots show that expression changes between the ML and LP subsets are uncorrelated with differential H3K4me3 marking (top panel, P = 0.4) but inversely correlated with H3K27me3 marking (bottom panel, P = 0.108). c Heatmaps of expression and epigenetic changes. Vertical columns represent log2-fold expression changes for expression, H3K4me3 binding and H3K27me3 binding, respectively. The left panel clusters the same log-fold changes as for (a). The right panel clusters the same log-fold changes as for (b) (red = increased; blue = decreased). FC fold change