Fig. 1From: Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraitsGlobal miRNA expression in sorted populations from mouse and human mammary glands. Mouse and human epithelial subsets are marked by unique miRNA expression signatures. a Multi-dimensional scaling plots indicate clear separation of the mammary stem cell (MaSC)/basal-enriched, luminal progenitor (LP), mature luminal (ML) and stromal subsets in both mouse (left panel) and human (right panel). Distances on the plot represent the log2 fold change for a typical miRNA between the samples. Stromal cells are well separated from the epithelial subsets, with a typical expression change of around 5 logs or 32-fold. The MaSC/basal subset is well separated from the luminal subsets with a typical expression change of around 4 logs or 16-fold. b Combined heat map shows hierarchical clustering of all conserved miRNAs in mouse and human epithelial subsets including stromal subsets (red = high expression; blue = low expression)Back to article page