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Figure 2 | Breast Cancer Research

Figure 2

From: Quantitative measurement of HER2 expression in breast cancers: comparison with ‘real-world’ routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival

Figure 2

Kaplan-Meier overall survival analyses by HER2 status. (A) Local HER2 IHC, (B) central HER2 IHC, (C) local HER2 FISH, (D) local HER2 status, (E) HERmark HER2 status, and (F) quantitative total HER2 (H2T) levels. The results of local HER2 tests were reported by participating study sites. Central HER2 IHC retest was performed retrospectively and categorized per ASCO/CAP guidelines for HER2 testing [7]. HERmark HER2 status was categorized as HERmark negative, HERmark equivocal, or HERmark positive by predefined H2T analytical cutoff values [17]. H2T low and H2T high were defined by a predetermined H2T clinical cutoff [16]. CI, confidence interval; FISH, fluorescence in situ hybridization; HER2, human epidermal growth factor receptor 2; H2T, quantitative total HER2 expression by HERmark; HR, hazard ratio; IHC, immunohistochemistry.

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