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Figure 1 | Breast Cancer Research

Figure 1

From: Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer

Figure 1

Correlation of the proportion of the genome with copy number aberrations and the patterns of copy number aberrations with Ki67 indices of proliferation and response to aromatase inhibitors. (A) A frequency plot of gains and losses (top panel) or amplifications (bottom panel) in 84 samples of ER-positive breast carcinomas from post-menopausal women before treatment with anastrozole. The proportion of tumors in which each bacterial artificial chromosome (BAC) clone is gained/amplified (green bars) or lost (red bars) is plotted (y-axis) for each BAC clone according to its genomic position (x-axis). (B) Scatter plots showing the correlation between the proportion of the genome with copy number aberrations on the y-axis and baseline Ki67 expression levels (left side) or the percentage decrease in Ki67 expression levels after 2 weeks of anastrozole (right side). Spearman correlation demonstrates a statistically significant positive correlation between proportion of the genome altered and baseline Ki67 expression levels. (C) Dot plots demonstrating the relationship between the distinct patterns of copy number aberrations defined by Hicks et al. and baseline Ki67 expression levels (left side) or the percentage decrease in Ki67 expression levels after 2 weeks of anastrozole (right side).

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