Daily coffee intake | Total | No intake | Low intake b | Moderately low intake b | Moderately high intake b | High intake b | P trend c | Per 100 mls |
---|---|---|---|---|---|---|---|---|
Number of participants | 335060 | 26734 | 87501 | 71684 | 79838 | 69303 | ||
Number of breast cancers | 10198 | 813 | 2542 | 2213 | 2518 | 2112 | ||
Premenopausal breast cancers | 1064 | 81 | 246 | 234 | 251 | 252 | ||
Adjusted Hazard Ratio (95% CI)d | 1.08 (0.83-1.40) | 1.00 | 1.23 (1.02-1.48) | 1.11 (0.93-1.34) | 1.15 (0.96-1.39) | 0.272 | 1.00 (0.98-1.03) | |
Postmenopausal breast cancers | 9134 | 732 | 2296 | 1979 | 2267 | 1860 | ||
Adjusted Hazard Ratio (95% CI)e | 1.02 (0.94-1.12) | 1.00 | 0.97 (0.91-1.03) | 0.97 (0.92-1.03) | 0.95 (0.89-1.01) | 0.055 | 0.99 (0.98-0.99) | |
ER+ and PR+ breast cancers | 3206 | 285 | 860 | 670 | 776 | 615 | ||
Adjusted Hazard Ratio (95% CI)f | 0.97 (0.84-1.11) | 1.00 | 0.96 (0.86-1.06) | 0.98 (0.88-1.08) | 0.91 (0.81-1.01) | 0.187 | 0.99 (0.97-1.00) | |
ER- and PR- breast cancers | 1052 | 93 | 269 | 222 | 257 | 211 | ||
Adjusted Hazard Ratio (95% CI)g | 0.99 (0.78-1.26) | 1.00 | 0.84 (0.70-1.01) | 0.89 (0.74-1.06) | 0.86 (0.71-1.05) | 0.135 | 0.99 (0.97-1.01) | |
Analysis by cohort-wide intake | ||||||||
Adjusted Hazard Ratio (95% CI)h | 0.99 (0.76-1.29) | 1.00 | 1.01 (0.84-1.20) | 1.01 (0.83-1.83) | 1.09 (0.88-1.35) | 0.501 | 1.00 (0.98-1.03) | |
Adjusted Hazard Ratio (95% CI)i | 1.03 (0.94-1.13) | 1.00 | 0.99 (0.92-1.06) | 0.98 (0.91-1.05) | 0.95 (0.88-1.02) | 0.067 | 0.99 (0.98-0.99) |