Table 2 The top-ranked signaling pathways associated with resistance to aromatase inhibitors a
| Â | Â | Deregulation in Res-Let vs MCF-7aro | Deregulation in Res-Ana vs MCF-7aro | Convergence on the AKT pathway |
|---|---|---|---|---|
KEGG pathway | Pathway ID | P -value b | P -value b | |
Wnt signaling pathway | hsa04310 | 7.1 × 10−9 | 7.0 × 10−7 |  |
TGF-β signaling pathway | hsa04350 | 2.1 × 10−8 | 3.0 × 10−4 |  |
Axon guidance | hsa04360 | 2.9 × 10−8 | 7.2 × 10−8 |  |
Regulation of actin cytoskeleton | hsa04810 | 1.0 × 10−7 | 1.5 × 10−5 |  |
MAPK signaling pathway | hsa04010 | 1.3 × 10−7 | 1.8 × 10−4 | Yes |
Focal adhesion | hsa04510 | 3.0 × 10−7 | 8.2 × 10−10 | Yes |
Adherens junction | hsa04520 | 2.0 × 10−6 | 2.4 × 10−6 |  |
Insulin signaling pathway | hsa04910 | 1.6 × 10−5 | 3.5 × 10−10 | Yes |
Ubiquitin-mediated proteolysis | hsa04120 | 1.1 × 10−4 | 4.5 × 10−5 |  |
ErbB signaling pathway | hsa04012 | 1.3 × 10−4 | 4.5 × 10−6 | Yes |
Tight junction | hsa04530 | 7.1 × 10−4 | NP | Yes |
Phosphatidylinositol signaling system | hsa04070 | 1.3 × 10−3 | NP | Yes |
mTOR signaling pathway | hsa04150 | 3.0 × 10−3 | 2.8 × 10−5 | Yes |