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Table 1 Deregulated microRNA expression associated with resistance to aromatase inhibitors

From: MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer

miRNA probe sets a

Fold change b

Res-Let

Res-Ana

Replicate 1

Replicate 2

Replicate 1

Replicate 2

miR-125b

1.87

2.44

1.86

2.13

miR-205

2.76

2.86

2.19

2.99

miR-30a

1.71

3.17

2.97

2.15

miR-424

−2.33

−2.07

−1.76

−1.74

miR-1292

−3.02

−1.73

−2.06

−2.06

miR-4492

−2.51

−1.77

−2.14

−2.02

miR-21

1.73

1.70

NC

NC

miR-125b-2

1.70

1.79

1.94

NC

miR-128-1/miR-128-2

1.70

1.70

NC

NC

miR-146b

1.96

1.97

1.78

NC

miR-301a

1.80

2.63

NC

NC

miR-494

3.14

1.70

NC

NC

miR-501

2.28

2.46

NC

NC

miR-1226

2.28

1.98

NC

NC

miR-1247

2.09

3.85

2.20

NC

miR-3135b

1.98

1.81

NC

NC

miR-3613

2.68

1.93

2.76

NC

miR-4667

1.91

2.30

1.91

NC

miR-23a

−1.75

−2.24

NC

NC

miR-23b

−2.08

−1.98

−1.72

NC

miR-92a-1

−1.73

−2.55

NC

−1.86

miR-193a

−2.03

−1.82

NC

NC

miR-193b

−2.04

−2.07

NC

NC

miR-324

−1.88

−1.85

NC

NC

miR-330

−1.72

−1.72

NC

NC

miR-4449

−1.76

−1.94

NC

NC

miR-491

−2.63

−2.41

NC

NC

miR-550a-1/miR-550a-2

−2.05

−1.78

NC

−3.07

miR-671

−1.73

−1.85

−1.81

NC

miR-744

−1.78

−1.87

NC

NC

miR-1180

−2.14

−1.78

NC

NC

miR-1287

−1.80

−1.88

NC

NC

miR-1296

−1.83

−2.83

NC

−2.90

miR-31

NC

3.68

1.88

4.39

miR-100

NC

2.43

2.40

2.31

miR-504

NC

NC

2.70

2.61

miR-1269

NC

NC

2.41

2.10

miR-3065

NC

NC

1.86

2.05

miR-29b-1

NC

NC

−2.11

−2.22

miR-342

−1.77

NC

−1.74

−1.77

miR-422a

NC

NC

−2.21

−1.84

miR-486

−2.46

NC

−1.88

−1.80

miR-4458

NC

NC

−2.73

−1.75

miR-4534

NC

NC

−2.42

−3.51

miR-4745

NC

−1.80

−2.74

−3.74

  1. aMicroRNAs (miRNAs) identified by the miRWalk database as being associated with a deregulated AKT pathway are shown in boldface type. bFold change (FC), corresponding to the ratio of the value for Res-Let or Res-Ana cells to that for MCF-7aro cells. Only probe sets with FC values superior to the cutoff selected (≥1.70 or less than or equal to −1.70) in the two independent cell culture replicates were considered to be differentially expressed. No change (NC) was defined as values −1.70 < FC <1.70.