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Table 4 Association between CYP19A1 single-nucleotide polymorphisms ( rs749292 and rs7172156 ) and mammographic density phenotypes, overall and stratified by median body mass index (23.6 kg/m 2 )

From: Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women

Mammographic density

 

Total

BMI ≤23.6

BMI >23.6

Genotype

β-value (95% CI)

P -value

β-value (95% CI)

P -value

β-value (95% CI)

P -value

  

( n  = 202)

 

( n  = 101)

 

( n  = 101)

 

rs749292

       

 Absolute density

AA

Reference

 

Reference

 

Reference

 
 

Aa

7.78 (−15.5, −0.12)

0.047

−13.0 (−22.2, −3.82)

0.006

1.91 (−9.86, 13.7)

0.748

 

aa

9.47 (−18.3, −0.61)

0.036

−14.1 (−24.8,−3.44)

0.010

−1.36 (−14.9, 12.2)

0.842

P-value for trend

  

0.032

 

0.015

 

0.587

 Percent density

AA

Reference

 

Reference

 

Reference

 
 

Aa

2.64 (−7.68, 2.39)

0.301

−3.01 (−10.0, 4.01)

0.396

2.44 (−3.93, 8.82)

0.449

 

aa

2.68 (−8.50, 3.14)

0.364

−2.33 (−10.5, 5.81)

0.571

0.42 (−6.92, 7.76)

0.910

P-value for trend

  

0.348

 

0.537

 

0.866

rs7172156

       

 Absolute density

AA

Reference

 

Reference

 

Reference

 
 

Aa

0.27 (−6.70, 7.24)

0.939

3.94 (−4.63, 12.5)

0.363

−4.87 (−15.9, 6.15)

0.768

 

aa

11.6 (1.43, 21.8)

0.026

18.2 (5.67, 30.8)

0.005

−2.15 (−16.6, 12.3)

0.382

P-value for trend

  

0.074

 

0.011

 

0.978

 Percent density

AA

Reference

 

Reference

 

Reference

 
 

Aa

1.52 (−6.09, 3.05)

0.512

1.15 (−5.38, 7.67)

0.728

−4.98 (−10.9, 0.93)

0.097

 

aa

2.23 (−4.45, 8.91)

0.512

2.01 (−7.57, 11.6)

0.678

−2.26 (−9.99, 5.47)

0.563

P-value for trend

  

0.792

 

0.573

 

0.847

  1. Multivariable linear regression model adjusted for age, parity, body mass index (BMI), 17-β-estradiol and high-density lipoprotein cholesterol. β: Estimated slope coefficient (for example, change in response) from reference (AA) to Aa and aa. Mammograms were taken within late follicular phase from days 7 to 12.