Study characteristics | Overall means (SD) | rs7172156 | rs749292 | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Major genotype, AA | Heterozygous genotype, Aa | Minor genotype, aa | P -value b | Major genotype, AA | Heterozygous genotype, Aa | Minor genotype, aa | P -value b | |||
( n = 82) a | ( n = 91) a | ( n = 31) a | ( n = 62 ) a | ( n = 93) a | ( n = 48) a | |||||
Age (yr) | 30.7 (3.07) | 30.2 (3.09) | 31.1 (3.12) | 30.7 (2.79) | 0.149 | 30.5 (2.99) | 31.0 (3.17) | 30.4 (3.00) | 0.425 | |
Education (total yr) | 16.1 (3.01) | 15.9 (2.65) | 16.2 (3.41) | 16.3 (2.73) | 0.701 | 15.8 (3.02) | 16.3 (3.15) | 16.2 (2.70) | 0.603 | |
Reproductive factorsc | ||||||||||
Age at menarche (yr) | 13.1 (1.36) | 13.1 (1.40) | 13.2 (1.43) | 13.1 (1.04) | 0.793 | 13.0 (1.14) | 13.2 (1.52) | 13.2 (1.20) | 0.536 | |
Menstrual cycle length (days) | 28.3 (3.42) | 28.7 (3.01) | 28.2 (3.66) | 27.8 (3.69) | 0.463 | 28.0 (3.48) | 28.3 (3.50) | 28.8 (3.22) | 0.503 | |
Number of children | 0.91 (1.13) | 0.85 (1.17) | 0.98 (1.11) | 0.84 (1.10) | 0.721 | 0.73 (1.01) | 0.99 (1.12) | 0.98 (1.28) | 0.320 | |
Weight at birth (g) | 3,389 (561) | 3,428 (554) | 3,369 (585) | 3,343 (519) | 0.701 | 3,274 (574) | 3,507 (530) | 3,328 (556) | 0.024 | |
Clinical parameters | ||||||||||
BMI (kg/m2)d | 24.4 (3.77) | 24.4 (3.74) | 24.2 (3.73) | 25.0 (4.00) | 0.606 | 24.8 (4.66) | 24.1 (3.19) | 24.3 (3.33) | 0.467 | |
Total tissue fat (%) (DXA)e | 34.2 (7.62) | 33.9 (7.69) | 33.7 (7.92 | 36.0 (6.41) | 0.328 | 35.1 (8.10) | 33.5 (7.51) | 33.9 (7.08) | 0.455 | |
Serum samplesf | ||||||||||
Total cholesterol (mmol/L) | 4.45 (0.78) | 4.55 (0.84) | 4.36 (0.75) | 4.40 (0.71) | 0.268 | 4.45 (0.77) | 4.33 (0.79) | 4.68 (0.76) | 0.044 | |
HDL-C (mmol/L) | 1.54 (0.33) | 1.55 (0.30) | 1.54 (0.36) | 1.51 (0.34) | 0.833 | 1.53 (0.32) | 1.54 (0.36) | 1.55 (0.31) | 0.940 | |
Serum hormonesf | ||||||||||
Estradiol (nmol/L) | 0.15 (0.06) | 0.15 (0.06) | 0.15 (0.07) | 0.14 (0.06) | 0.644 | 0.14 (0.06) | 0.15 (0.07) | 0.14 (0.06) | 0.646 | |
SHBG (nmol/L) | 51.9 (19.5) | 51.7 (18.1) | 52.7 (22.0) | 50.2 (15.3) | 0.828 | 51.6 (17.0) | 53.3 (22.8) | 50.0 (15.5) | 0.626 | |
Salivary hormones g | ||||||||||
Midmenstrual estradiol (pmol/L) | 18.2 (8.98) | 19.4 (9.52) | 19.0 (8.81) | 12.6 (5.39) | 0.001 | 16.3 (7.67) | 18.4 (9.59) | 19.8 (9.03) | 0.095 | |
Lifestyle factors c | ||||||||||
Current smokers (%) | 22.3 | 19.3 | 22.8 | 28.1 | 0.586 | 13.8 | 23.2 | 10.8 | 0.768 | |
Alcohol (U/wk) | 2.89 (3.38) | 3.03 (3.41) | 2.84 (3.38) | 2.67 (3.38) | 0.865 | 2.52 (3.07) | 3.07 (3.41) | 3.08 (3.74) | 0.561 | |
Energy intake (kJ/day) | 8,093 (1,900) | 8,371 (1,837) | 8,085 (1,754) | 7,381 (2,314) | 0.046 | 7,749 (1,975) | 8,087 (2,005) | 8,495 (1,480) | 0.123 | |
Previous use of OC (%) | 83.4 | 81.9 | 85.7 | 81.2 | 0.747 | 81.0 | 83.9 | 85.7 | 0.788 | |
Leisure time MET (hr/wk) | 57.6 (88.6) | 68.2 (133) | 48.4 (32.0) | 56.7 (42.9) | 0.337 | 51.9 (39.4) | 63.4 (125) | 53.6 (36.8) | 0.685 | |
Mammographic density e | ||||||||||
Total area (cm2) | 137 (62.5) | 131 (64.9) | 137 (59.6) | 155 (62.8) | 0.209 | 149 (69.5) | 132 (61.1) | 129 (52.6) | 0.161 | |
Absolute density (cm2) | 34.7 (23.4) | 34.7 (22.4) | 32.8 (23.8) | 40.7 (24.4) | 0.283 | 39.1 (26.2) | 33.5 (23.8) | 32.3 (17.4) | 0.238 | |
Percent density (%) | 29.8 (19.0) | 31.5 (19.0) | 28.6 (20.4) | 28.8 (14.5) | 0.594 | 30.1 (18.1) | 29.8 (20.2) | 29.9 (17.9) | 0.995 |