Figure 1
Mean salivary 17β-estradiol levels across menstrual cycles for rs749292 and rs7172156 , adjusted for age, body mass index and parity. (a) rs749292 mean estradiol levels: minor homozygous genotype (aa) (n = 46), 19.8 pmol/L; heterozygous genotype (Aa) (n = 86), 18.7 pmol/L; and major homozygous genotype (AA) (n = 57), 16.0 pmol/L (P = 0.075). (b) rs749292 and low body mass index (BMI ≤23.6 kg/m2): aa (n = 25), 17.5 pmol/L; Aa (n = 46), 17.4 pmol/L; and AA (n = 25), 14.7 pmol/L (P = 0.294). (c) rs749292 and high BMI >23.6 kg/m2: aa (n = 21), 22.3 pmol/L; Aa (n = 40), 19.9 pmol/L; and AA (n = 30), 17.6 pmol/L (P = 0.265). (d) rs7172156 mean estradiol levels: aa (n = 29), 12.3 pmol/L; Aa (n = 83), 19.2 pmol/L; and AA (n = 78), 19.3 pmol/L (P = 0.001). (e) rs7172156 and low BMI ≤23.6 kg/m2: aa (n = 12), 12.9 pmol/L; Aa (n = 41), 17.5 pmol/L; and AA (n = 45), 16.9 pmol/L (P = 0.208). (f) rs7172156 and high BMI >23.6 kg/m2: aa (n = 17), 12.0 pmol/L; Aa (n = 42), 20.9 pmol/L; and AA (n = 33), 22.4 pmol/L (P = 0.001).