Skip to main content
Figure 5 | Breast Cancer Research

Figure 5

From: A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

Figure 5

Chromatin immunoprecipitation analysis for FOXO3a promoter recruitment. (A) Chromatin immunoprecipitation (ChIP) assays for FOXO3a following ETP-45658 treatment at three or six hours of MCF-7 or MDA-MB231 cells for CCG2, CDKN1B, BCL2L11or FASLG. IgG indicates no specific antibody used and for simplicity, only inputs from our MCF-7 samples are shown. (B and C) Quantification of our ChIP gels normalised to inputs from each respective cell line. Error bars indicate standard deviation, N = 3.

Back to article page