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Figure 4 | Breast Cancer Research

Figure 4

From: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis

Figure 4

Gas chromatography-mass spectrometry (GCMS) analysis of tumor fatty acids. (A) Tumor fatty acid contents from Neu (n = 8) and Neu/S14 (n = 7) mice. P ≤0.05. (B) Tumor fatty acid contents from polyomavirus middle T antigen (PyMT) (n = 6) and S14−/− (S14−/−) (n = 6) mice. Fatty acids are grouped according to chain length. Those with carbon chains ≤16 are on the left of each graph, and those with carbon chains >16 are on the right of each graph. (C) Immunoblot analysis of proteins in cytosolic lysates used for fatty acid synthase (FASN) activity assay showing FASN (top) and S14 (middle). β-Tubulin was used as a loading control. (D) FASN activity in cytosolic lysates from PyMT or S14−/− tumors. P = 0.035. Graphs are mean + standard error of the mean.

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