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Figure 1 | Breast Cancer Research

Figure 1

From: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis

Figure 1

Tumor histology, latency, and growth in polyomavirus middle T antigen (PyMT) mice with and without S14. H&E-stained sections of tumors from PyMT (A), and PyMT/S14−/− (S14−/−) mice (B, C). A representative solid tumor is shown in (B). A tumor with a cystic morphology is shown in (C). Images were captured at 10x magnification. (D) Kaplan Meier survival curve; tumors appeared with median latencies of 61 days (PyMT; n = 15) and 64 days (S14−/−; n = 14); hazard ratio (HR) 1.187 (0.588 to 2.55); log rank P-value = 0.62. (E) Tumor growth rates; PyMT n = 12, S14−/− n = 10; *P = 0.02. (F) Expression of S14 (THRSP) and (G) keratin 18 (Krt18) in tumors from S14−/− (n = 13) relative to PyMT (n = 14) mice. Graphs are mean + standard error of the mean.

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Breast Cancer Research

ISSN: 1465-542X

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