SNP (major/minor allele) | Gene | Minor allele frequency | N (WW/WV/VV) | beta | SE |
P
|
P
ACT
¶
|
---|
rs7489119 (C/A) |
SLCO1B1
| 0.041 | 258/23/1 | −4.22 | 1.25 | 0.0008 | 0.018 |
rs5933863 (G/A) |
ARSC
| 0.15 | 200/79/5 | 1.87 | 0.75 | 0.013 | 0.025 |
- *Based on linear regression model adjusting for age and BMI (kg/m2) at time of on-EPT mammogram, time interval and BMI change between the two mammograms, and mammographic density of on-EPT mammogram. Additive genetic model was used. ¶Multiple testing corrected P value; P ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [33]. EPT, estrogen and progestin combined therapy; SNP, single nucleotide polymorphisms; SE, standard error; BMI, body mass index.