Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes

Table 1 Results from univariate logistic regression with HRD scores or clinical variables as predictors of BRCA1/2 deficiency

	Number of patients	Number BRCA1 / 2 deficient	P value	OR (95% CI)
HRD-LOH score	197	38	1.3 × 10^-17	22 (8.4, 58)
HRD-TAI score	197	38	1.5 × 10^-19	17 (7.2, 41)
HRD-LST score	197	38	3.5 × 10^-18	19 (7.7, 46)
HRD-mean score	197	38	1.1 × 10^-24	90 (22, 360)
Age at diagnosis	196	37	0.0071	0.96 (0.94, 0.99)
Stage			0.88
I	13	3		1
II	121	23		0.78 (0.2, 3.1)
III	54	9		0.67 (0.15, 2.9)
IV	3	1		1.7 (0.11, 25)
Cancer subtype			1.2 × 10^-5
TNBC	52	23		8.5 (2.3, 31)
ER ^–/HER2 ⁺	35	3		1
ER ⁺/HER2 ^–	50	5		1.2 (0.26, 5.3)
ER ⁺/HER2 ⁺	60	7		1.4 (0.34, 5.8)
Grade^a (categorical)			0.0011	NA
1	17	0		1
2	102	14		∞ (0, ∞)
3	71	21		∞ (0, ∞)
Grade (numerical)			0.00053	3.1 (1.6, 6.3)

Odds ratios for HRD scores are reported per interquartile range of the score. The odds ratio for age is reported per year. The odds ratio for grade (numerical) is per unit. CI, confidence interval; ER, estrogen receptor; HER2, tyrosine kinase-type cell surface receptor HER2; HRD, homologous recombination deficiency; HRD-LOH, homologous recombination deficiency-loss of heterozygosity; HRD-LST, homologous recombination deficiency-large-scale state transition; HRD-Mean, mean of the three HRD scores; HRD-TAI, homologous recombination deficiency-telomeric allelic imbalance; NA, not available; OR, odds ratio; TNBC, triple-negative breast cancer. ^aThe odds ratio for categorical grade is inestimable due to zero BRCA1/2-deficient grade 1 tumors.

ISSN: 1465-542X