Figure 1From: Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortiaProposed strategy for application of pathology likelihood ratios in multifactorial likelihood analysis of BRCA1 or BRCA2 rare sequence variants. Cases carrying a variant of uncertain clinical significance, and with information on relevant pathology variables, are first assessed to determine that breast tumor pathology information was not a criterion used to trigger gene testing. ER, estrogen-receptor breast tumor status; PR, progesterone-receptor breast tumor status; HER2, HER2 breast tumor status; TN, triple-negative breast tumor status; Not TN, breast tumor status not triple-negative, after measurement of ER, PR, and HER2 status; ER-neg, ER-negative status; ER-pos, ER-positive status; G, grade; <50, breast cancer diagnosis at younger than 50 years for tumor with relevant pathology data; ≥50, breast cancer diagnosis at 50 to 70 years for tumor with relevant pathology data.Back to article page