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Figure 2 | Breast Cancer Research

Figure 2

From: Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis

Figure 2

Adrenomedullin overexpression increases osteolytic bone destruction and decreases survival in mice. Two control (G8 and G26) and two adrenomedullin (AM)-overexpressing (A39 and A51) MDA-MB-231 clones were injected into the left cardiac ventricle of female athymic nude mice (n = 12/cell line). (A) Representative radiographs of the bone destruction due to control (left panel) and AM-overexpressing clones (right panel) at 4 weeks after tumor cell inoculation. Original magnification, ×4. Arrows point to osteolytic lesions. (B) Quantitative radiographic lesion analysis of MDA-MB-231 control and AM+ clones over time (G8, gray square; G26, black square; A39, gray triangle; A51, black triangle). *P < 0.05, **P < 0.01. (C) Mouse survival. The two control clones (G8 and G26, black squares) and the two AM+ clones (A39 and A51, black triangles) were grouped together in the analysis.

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