Table 1 Recent large studies investigating the impact of age on breast cancer prognosis
| Â | Young age, years (n) | Control age, years (n) | Outcome definition | Impact of young age on outcomea | Factors controlled in multivariate model | |
|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | |||||
Gnerlich et al. 2009 [5] | <40 (15,548) | ≥40 (227,464) | BC-specific survival | 1.39 | 1.34-1.45 | T, N, grade, race, marital status, ER, PgR, local therapy |
Fredholm et al. 2009 [6] | <35 (378) | 50-69 (13,486) | BC-specific survival | 1.76 | 1.36-2.28 | T, N, grade, ER, multifocality, local and systemic therapy |
Cancello et al. 2010 [7] | <35 (315) | 35-50 (2,650) | BC-related event | 1.7 | 1.33-2.18 | T, N, grade, histology, ER, HER2, PgR, ki67 vascular invasion |
Han et al. 2010 [8] | <35 (1,443) | 40-50 (6,354) | Overall survival | 30-34 years: 1.43 26–29 years: 1.97 | 1.18-1.74 1.48-2.62 | T, N, ER, systemic therapy |
Azim et al. 2012 [9] | ≤40 (339) | >40 (2,562) | Relapse-free survival | 1.34 | 1.10-1.63 | T, N, grade, BC molecular subtype, systemic therapy |