Figure 3

Plasma DNA analyses from the index patient. (a) Sizing of the plasma DNA fragments with a microfluidic device, that is the Agilent 2100 Bioanalyzer. All three plasma samples from the index patient (P1, P2, and P3, which correspond to the first, second, and third blood sample) demonstrated enrichment of short DNA fragments (size range 85 to 250 bps), whereas longer DNA size fragments (250 to 450 bps) were barely present. (b) Whole-genome sequencing (plasma-Seq) profiles of the three blood samples.