Figure 1From: Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal diseaseFluorescence-activated cell sorting (FACS) purification of pure luminal (pLUM) versus pure luminobasal (pLB) subpopulations. Left panel: FACS of a mixed-cell T47Dco xenograft isolated from an estrogen (E) + progesterone (P) treated mouse, using CLD3- fluorescein isothiocyanate (FITC) (x-axis) and CD49f-PE-CY5 (y-axis), showing both cell populations. pLB (right panel) and pLUM (center panel) were separately collected and expanded in culture; cell lines were derived after re-sorting.Back to article page