Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression

Breast Cancer Research

Table 1 Correlation between Cox-2 and Ido-1 expression and various clinicopathologic factors

Parameters	Category	No. of cases	Cox-2 expression (tumor)		Pvalue	Ido-1 expression (CAF)		Pvalue
Parameters	Category	No. of cases	Low exp.	High exp.	Pvalue	Low exp.	High exp.	Pvalue
Age (years)	<60 years	141	73	68	0.444	69	72	0.647
	≧60 years	61	28	33		32	29
Primary tumor (T)	T1	82	45	37	0.002	44	38	<0.001
	T2	96	52	44		54	42
	T3-4	24	4	20		3	21
Nodal status (N)	N0	117	77	40	<0.001	76	41	<0.001
	N1-N2	85	24	61		25	60
Stage	I	63	37	26	0.006	37	26	0.002
	II	115	59	56		60	55
	III	24	5	19		4	20
Histologic grade	Grade I	18	13	5	0.122	15	3	0.003
	Grade II	141	69	72		71	70
	Grade III	43	19	24		15	28
CAF Ido-1 expression	Low Exp. (<medium)	101	65	35	<0.001
	High Exp. (≧medium)	101	35	65

ISSN: 1465-542X