Figure 5

Coexpression of cancer COX-2 and stromal IDO predicted worse patient survival. (A) Immunohistochemical staining showed COX-2 expression in breast tumor tissues and IDO expression in tumor stroma. (B) High COX-2 expression in tumor tissues was associated with reduced disease-specific and metastasis-free survival. (C) High IDO expression in tumor stroma also was associated with reduced disease-specific and metastasis-free survival. (D) Coexpression of tumor COX-2 and stroma IDO predicted worse patient survival.