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Table 3 Least-square mean change in mammographic percentage density by genotype and treatment arm, adjusted

From: Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study

Genotype

Placebo

 

ET

 

EPT

  
 

Mean (N)

SEM

P*

Mean (N)

SEM

P

Mean (N)

SEM

P

P †

COMT Val158Met

          

Val/Val

- 0.1 (30)

1.4

Ref.

3.7 (30)

1.4

Ref.

8.0 (12)

2.3

Ref.

 

Val/Met

0.5 (45)

1.2

0.74

4.3 (48)

1.1

0.72

6.2 (19)

1.9

0.54

 

Met/Met

- 0.6 (19)

1.8

0.82

6.0 (25)

1.6

0.27

9.8 (3)

4.5

0.72

0.77

CYP1B1 Val432Leu

          

Val/Val

- 0.7 (15)

1.9

Ref.

4.7 (23)

1.6

Ref.

6.9 (7)

2.9

Ref.

 

Leu/Val

- 0.01 (42)

1.2

0.75

5.8 (44)

1.2

0.57

1.3 (13)

2.1

0.11

 

Leu/Leu

0.9 (36)

1.2

0.47

3.6 (37)

1.2

0.61

14.5 (13)

2.1

0.03

0.0004

UGT1A1

          

<7/<7 TA repeats

0.3 (37)

1.3

Ref.

5.7 (50)

1.1

Ref.

7.1 (18)

1.9

Ref.

 

<7/≥ 7 TA repeats

- 0.5 (43)

1.2

0.60

3.3 (39)

1.3

0.15

8.7 (12)

2.3

0.57

 

≥ 7/≥ 7 TA repeats

0.6 (14)

2.1

0.92

4.4 (14)

2.1

0.58

5.4(3)

4.6

0.74

0.77

AKR1C4 L311V

          

Leu/Leu

- 0.3 (72)

0.9

Ref.

4.3 (79)

0.8

Ref.

4.0 (25)

1.6

Ref.

 

Leu/Val

1.5 (21)

1.6

0.30

5.5 (25)

1.5

0.47

16.7 (7)

2.8

0.0001

 

Val/Val

0.6 (1)

 

0.90

(0)

  

29.3 (1)

 

0.0007

0.001

  1. Figures are adjusted for race, age at baseline, years since menopause, body mass index (BMI) at baseline, change in BMI on trial, mammographic percentage density at baseline, past use of hormone therapy and study group.
  2. *Analysis of covariance P for comparison of means; †analysis of covariance P for ET/EPT × genotype interaction. AKR1C4, aldo-keto reductase 1C4; COMT, catechol-O-methyltransferase; CYP1B1, cytochrome P450 1B1; EPT, estrogen and progestin therapy; ET, estrogen therapy; UGT1A1, UDP-glucuronosyltransferase 1A1.